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Literature summary for 2.6.1.16 extracted from

  • Chmara, H.; Andruszkiewicz, R.; Borowski, E.
    Inactivation of glucosamine-6-phosphate synthethase from Salmonella typhimurium LT2 by fumarolyl diaminopropanoic acid derivatives, a novel group of glutamine analogs (1985), Biochim. Biophys. Acta, 870, 357-366.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
1,1'-dithiodiformamidine irreversible inhibition Salmonella enterica subsp. enterica serovar Typhimurium
4-Glutamylhydroxamate
-
 Salmonella enterica subsp. enterica serovar Typhimurium
5,5'-dithionitrobenzoic acid irreversible inhibition Salmonella enterica subsp. enterica serovar Typhimurium
6,6'-Dithiodinicotinic acid irreversible inhibition Salmonella enterica subsp. enterica serovar Typhimurium
6-diazo-5-oxo-L-norleucine
-
 Salmonella enterica subsp. enterica serovar Typhimurium
albizziin
-
 Salmonella enterica subsp. enterica serovar Typhimurium
anticapsin
-
 Salmonella enterica subsp. enterica serovar Typhimurium
azaserine
-
 Salmonella enterica subsp. enterica serovar Typhimurium
iodoacetamide irreversible inhibition Salmonella enterica subsp. enterica serovar Typhimurium
iodoacetate
-
 Salmonella enterica subsp. enterica serovar Typhimurium
N-ethylmaleimide irreversible inhibition Salmonella enterica subsp. enterica serovar Typhimurium
N3-(4-Methoxyfumaroyl)-L-2,3-diaminopropanoic acid L-glutamine and some analogs protect Salmonella enterica subsp. enterica serovar Typhimurium
N3-fumaramoyl-L-2,3-diaminopropanoic acid
-
 Salmonella enterica subsp. enterica serovar Typhimurium
N3-fumaroyl-L-2,3-diaminopropanoic acid
-
 Salmonella enterica subsp. enterica serovar Typhimurium
N3-fumarylcarboxyamido-L-2,3-diaminopropionic acid
-
 Salmonella enterica subsp. enterica serovar Typhimurium
N4-(4-Methoxyfumaroyl)-L-2,4-diaminobutanoic acid
-
 Salmonella enterica subsp. enterica serovar Typhimurium
p-hydroxymercuribenzoate
-
 Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.3
-
 L-glutamine pH 7.5, 37°C Salmonella enterica subsp. enterica serovar Typhimurium

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
 LT2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamine + D-fructose 6-phosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-glutamate + D-glucosamine 6-phosphate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00027
-
 N3-(4-Methoxyfumaroyl)-L-2,3-diaminopropanoic acid pH 7.5, 37°C Salmonella enterica subsp. enterica serovar Typhimurium
0.00028
-
 anticapsin pH 7.5, 37°C Salmonella enterica subsp. enterica serovar Typhimurium
0.0075
-
 6-diazo-5-oxo-L-norleucine pH 7.5, 37°C Salmonella enterica subsp. enterica serovar Typhimurium
0.008
-
 N3-fumaroyl-L-2,3-diaminopropanoic acid pH 7.5, 37°C Salmonella enterica subsp. enterica serovar Typhimurium
0.019
-
 N3-fumaramoyl-L-2,3-diaminopropanoic acid pH 7.5, 37°C Salmonella enterica subsp. enterica serovar Typhimurium
0.095
-
 4-Glutamylhydroxamate pH 7.5, 37°C Salmonella enterica subsp. enterica serovar Typhimurium
0.77
-
 azaserine pH 7.5, 37°C Salmonella enterica subsp. enterica serovar Typhimurium
1.5
-
 albizziin pH 7.5, 37°C Salmonella enterica subsp. enterica serovar Typhimurium