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Literature summary for 2.6.1.13 extracted from

  • Liu, Y.; Wu, L.; Li, K.; Liu, F.; Wang, L.; Zhang, D.; Zhou, J.; Ma, X.; Wang, S.; Yang, S.
    Ornithine aminotransferase promoted the proliferation and metastasis of non-small cell lung cancer via upregulation of miR-21 (2019), J. Cell. Physiol., 234, 12828-12838 .
    View publication on PubMed
Search for more literature for 2.6.1.13

Application

Application Comment Organism
diagnostics OAT may be a potential biomarker for the diagnosis and therapeutic outcome monitoring of non-small cell lung cancer (NSCLC). Relationship between OAT mRNA expression and clinicopathological features in patients with NSCLC, overview Homo sapiens
medicine inhibition of OAT may represent a therapeutic strategy in treatment of non-small cell lung cancer (NSCLC) Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information overexpression of OAT promoting the growth and metastasis of A549 cells. OAT knockdown in H-1299 cells transfected with OAT siRNA results in a lower expression level of OAT mRNA and protein than in the control group. Knockdown of OAT suppresses cell proliferation, decreases the number of colonies, invades cells, and migrates cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine + 2-oxoglutarate Homo sapiens
-
 L-glutamate 5-semialdehyde + L-glutamate
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens P04181
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
NCI-H1299 cell
-
 Homo sapiens
-
NCI-H226 cell
-
 Homo sapiens
-
non-small cell lung cancer cell NSCLC cell. Upregulation of OAT in NSCLC tissues Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine + 2-oxoglutarate
-
 Homo sapiens L-glutamate 5-semialdehyde + L-glutamate
-
 r

Synonyms

Synonyms Comment Organism
OAT
-
 Homo sapiens
ornithine aminotransferase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate PLP, dependent on Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is upregulated in non-small cell lung cancer cells up

General Information

General Information Comment Organism
malfunction overexpression of OAT promotes the growth and metastasis of A-549 lung cancer cells, and overexpression of OAT also promotes the epithelial-mesenchymal transition (EMT) of OAT-overexpressing A549 cells. Knockdown of OAT inhibits the proliferation and metastasis of H-1299 cells Homo sapiens
physiological function ornithine aminotransferase (OAT) promotes the proliferation, invasion, and migration, inhibits the apoptosis, and alters cell cycle of non-small cell lung cancer cells (NSCLC cells). Also the involvement of OAT-miR-21-glycogen synthase kinase-3beta signaling in the functional role of OAT in NSCLC is revealed. Glycogen synthase kinase-3beta (GSK-3beta) is a direct target of miR-21 in NSCLC Homo sapiens