Protein Variants | Comment | Organism |
---|---|---|
L402P | mutation based on mutant identified in humans, abrogates both OAT enzymatic activity and ability to modulate the developmental phenotype | Xenopus laevis |
R180T | mutation based on mutant identified in humans, abrogates both OAT enzymatic activity and ability to modulate the developmental phenotype | Xenopus laevis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Xenopus laevis | Q98TS5 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
OAT | - |
Xenopus laevis |
General Information | Comment | Organism |
---|---|---|
physiological function | ornithine-delta-aminotransferase OAT is essential for Xenopus embryonic development, and overexpression of OAT produces a ventralized phenotype characterized by a small head, lack of axial structure, and defective expression of neural developmental markers. Substitution of both Arg 180 and Leu 402 abrogates both OAT enzymatic activity and ability to modulate the developmental phenotype. Neurogenesis is inhibited by OAT during Xenopus embryonic development | Xenopus laevis |