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Literature summary for 2.6.1.13 extracted from

  • Peng, Y.; Cooper, S.K.; Li, Y.; Mei, J.M.; Qiu, S.; Borchert, G.L.; Donald, S.P.; Kung, H.F.; Phang, J.M.
    Ornithine-delta-aminotransferase inhibits neurogenesis during Xenopus embryonic development (2015), Invest. Ophthalmol. Vis. Sci., 56, 2486-2497.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
L402P mutation based on mutant identified in humans, abrogates both OAT enzymatic activity and ability to modulate the developmental phenotype Xenopus laevis
R180T mutation based on mutant identified in humans, abrogates both OAT enzymatic activity and ability to modulate the developmental phenotype Xenopus laevis

Organism

Organism UniProt Comment Textmining
Xenopus laevis Q98TS5
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-

Synonyms

Synonyms Comment Organism
OAT
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Xenopus laevis

General Information

General Information Comment Organism
physiological function ornithine-delta-aminotransferase OAT is essential for Xenopus embryonic development, and overexpression of OAT produces a ventralized phenotype characterized by a small head, lack of axial structure, and defective expression of neural developmental markers. Substitution of both Arg 180 and Leu 402 abrogates both OAT enzymatic activity and ability to modulate the developmental phenotype. Neurogenesis is inhibited by OAT during Xenopus embryonic development Xenopus laevis