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Literature summary for 2.6.1.13 extracted from
- Regulation of ornithine aminotransferase gene expression and activity by all-transretinoic acid in Caco-2 intestinal epithelial cells (2008), J. Nutr. Biochem., 19, 674-681.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| retinoic acid | treatment of cells induces increase in ornithine aminotransferase expression and activity which results in decreased intracellular concentrations of ornithine and polyamines putrescine, spermidine and spermine. Changes occur concomitantly with a decrease in the total number of cells, and the increase in ornithine aminotransferase activity is due to increased mRNA expression. In cells treated with 1 microM retinoic acid, addition of 10 microM putrescine to culture medium restores both cellular levels of polyamines and cell numbers to the values for the control group | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Caco-2 cell | - |
Homo sapiens | - |
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