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Literature summary for 2.6.1.13 extracted from

  • Ventura, G.; De Bandt, J.P.; Segaud, F.; Perret, C.; Robic, D.; Levillain, O.; Le Plenier, S.; Godard, C.; Cynober, L.; Moinard, C.
    Overexpression of ornithine aminotransferase: consequences on amino acid homeostasis (2009), Br. J. Nutr., 101, 843-851.
    View publication on PubMed
Search for more literature for 2.6.1.13

Application

Application Comment Organism
medicine transgenic mice that specifically overexpress human ornithine aminotransferase in the liver, kidneys and intestine exhibit higher enzyme activity in the liver than wild-type, but there are no differences in kinetic parameters between wild-type and transgenic animal. Ornithine aminotransferase overexpression decreases plasma and liver ornithine concentrations but does not affect glutamine or arginine homeostasis. There is an inverse relationship between ornithine levels and enzyme activity Mus musculus
medicine transgenic mice that specifically overexpress human ornithine aminotransferase in the liver, kidneys and intestine exhibit higher enzyme activity in the liver than wild-type, but there are no differences in kinetic parameters between wild-type and transgenic animal. Ornithine aminotransferase overexpression decreases plasma and liver ornithine concentrations but does not affect glutamine or arginine homeostasis. There is an inverse relationship between ornithine levels and enzyme activity Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information transgenic mice that specifically overexpress human ornithine aminotransferase in the liver, kidneys and intestine exhibit higher enzyme activity in the liver than wild-type, but there are no differences in kinetic parameters between wild-type and transgenic animal. Ornithine aminotransferase overexpression decreases plasma and liver ornithine concentrations but does not affect glutamine or arginine homeostasis. There is an inverse relationship between ornithine levels and enzyme activity Mus musculus
additional information transgenic mice that specifically overexpress human ornithine aminotransferase in the liver, kidneys and intestine exhibit higher enzyme activity in the liver than wild-type, but there are no differences in kinetic parameters between wild-type and transgenic animal. Ornithine aminotransferase overexpression decreases plasma and liver ornithine concentrations but does not affect glutamine or arginine homeostasis. There is an inverse relationship between ornithine levels and enzyme activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.17
-
 2-oxoglutarate wild-type, pH 7.5, 37°C Mus musculus
2.69
-
 2-oxoglutarate transgenic mouse, pH 7.5, 37°C Homo sapiens
13.94
-
 L-ornithine wild-type, pH 7.5, 37°C Mus musculus
15.32
-
 L-ornithine transgenic mouse, pH 7.5, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine + 2-oxoglutarate
-
 Mus musculus glutamate + DELTA1-pyrroline-5-carboxylate
-
 ?
L-ornithine + 2-oxoglutarate
-
 Homo sapiens glutamate + DELTA1-pyrroline-5-carboxylate
-
 ?