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Literature summary for 2.6.1.13 extracted from
- Ornithine aminotransferase, a potential target for the treatment of hyperammonemias (2000), Curr. Drug Targets, 1, 119-153.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-aminooxyacetic acid | - |
Homo sapiens |  |
| 2-aminooxyacetic acid | almost complete inhibition at 0.2 mM | Rattus norvegicus | |
| 5-Fluoromethylornithine | competitive | Homo sapiens | |
| 5-Fluoromethylornithine | - |
Rattus norvegicus | |
| L-canaline | irreversible | Homo sapiens | |
| L-canaline | - |
Rattus norvegicus | |
| additional information | overview: inhibitors | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial matrix | - |
Homo sapiens | 5759 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45000 | - |
- |
Rattus norvegicus |
| 45000 | - |
mature protein | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-ornithine + 2-oxoglutarate | Rattus norvegicus | - |
DELTA1-pyrroline-5-carboxylate + L-glutamate | - |
? | |
| L-ornithine + 2-oxoglutarate | Homo sapiens | urea cycle | DELTA1-pyrroline-5-carboxylate + L-glutamate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
hereditary enzyme deficiency | - |
| Rattus norvegicus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| L-ornithine + a 2-oxo carboxylate = L-glutamate 5-semialdehyde + an L-amino acid | mechanism | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| retina | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-ornithine + 2-oxoglutarate | - |
Rattus norvegicus | DELTA1-pyrroline-5-carboxylate + L-glutamate | - |
? | |
| L-ornithine + 2-oxoglutarate | - |
Homo sapiens | DELTA1-pyrroline-5-carboxylate + L-glutamate | glutamate-gamma semialdehyde spontaneously cyclizes to form DELTA1-pyrroline-5-carboxylate | ? | |
| L-ornithine + 2-oxoglutarate | - |
Rattus norvegicus | DELTA1-pyrroline-5-carboxylate + L-glutamate | glutamate-gamma semialdehyde spontaneously cyclizes to form DELTA1-pyrroline-5-carboxylate | ? | |
| L-ornithine + 2-oxoglutarate | urea cycle | Homo sapiens | DELTA1-pyrroline-5-carboxylate + L-glutamate | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Homo sapiens | |
| pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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