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Literature summary for 2.6.1.122 extracted from

  • Sweet, C.; Ribeiro, A.; Raetz, C.
    Oxidation and transamination of the 3''-position of UDP-N-acetylglucosamine by enzymes from Acidithiobacillus ferrooxidans Role in the formation of lipid a molecules with four amide-linked acyl chains (2004), J. Biol. Chem., 279, 25400-25410 .
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Acidithiobacillus ferrooxidans

Protein Variants

Protein Variants Comment Organism
K190A inactive Acidithiobacillus ferrooxidans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-3-dehydro-alpha-D-glucosamine + L-glutamate Acidithiobacillus ferrooxidans
-
 UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
-
 ?

Organism

Organism UniProt Comment Textmining
Acidithiobacillus ferrooxidans Q6QHI5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-3-dehydro-alpha-D-glucosamine + L-glutamate
-
 Acidithiobacillus ferrooxidans UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate
-
 ?

Synonyms

Synonyms Comment Organism
gnnB
-
 Acidithiobacillus ferrooxidans

General Information

General Information Comment Organism
physiological function enzyme participates, together with EC 1.1.1.374, UDP-N-acetylglucosamine 3-dehydrogenase, in the synthesis of 2,3-diamino-2,3-dideoxy-D-glucopyranose, a component of lipid A in some bacteria Acidithiobacillus ferrooxidans