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Literature summary for 2.6.1.115 extracted from

  • Awodi, U.; Ronan, J.; Masschelein, J.; De Los Santos, E.; Challis, G.
    Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis (2016), Chem. Sci., 8, 411-415 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Streptomyces coelicolor

Organism

Organism UniProt Comment Textmining
Streptomyces coelicolor
-
-
-
Streptomyces coelicolor M145
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant protein Streptomyces coelicolor

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate
-
Streptomyces coelicolor (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine
-
?
(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate
-
Streptomyces coelicolor M145 (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine
-
?
1,1-dicyclopentylmethanamine + 2-oxoglutarate
-
Streptomyces coelicolor 1-dicyclopentylmethanal + L-glutamate
-
?
1,1-dicyclopentylmethanamine + 2-oxoglutarate
-
Streptomyces coelicolor M145 1-dicyclopentylmethanal + L-glutamate
-
?
2-methylpropan-1-amine + 2-oxoglutarate
-
Streptomyces coelicolor 2-methylpropanal + L-glutamate
-
?
butan-1-amine + 2-oxoglutarate
-
Streptomyces coelicolor butanal + L-glutamate
-
?
additional information enzyme displays broad substrate tolerance. Highest level of activity is observed for octylamine using pyruvate as the cosubstrate. Only L-alanine is formed from pyruvate Streptomyces coelicolor ?
-
?
additional information enzyme displays broad substrate tolerance. Highest level of activity is observed for octylamine using pyruvate as the cosubstrate. Only L-alanine is formed from pyruvate Streptomyces coelicolor M145 ?
-
?
octanal + L-alanine
-
Streptomyces coelicolor octyl-1-amine + pyruvate
-
r
octyl-1-amine + pyruvate
-
Streptomyces coelicolor octanal + L-alanine
-
r
phenylamine + 2-oxoglutarate
-
Streptomyces coelicolor benzaldehyde + L-glutamate
-
?

Synonyms

Synonyms Comment Organism
cpkG
-
Streptomyces coelicolor