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Literature summary for 2.6.1.1 extracted from
- Cytosolic aspartate aminotransferase mediates the mitochondrial membrane potential and cell survival by maintaining the calcium homeostasis of BV2 microglia (2018), NeuroReport, 29, 99-105 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-aspartate + 2-oxoglutarate | Mus musculus | - |
oxaloacetate + L-glutamate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| BV-2 cell | - |
Mus musculus | - |
| microglia | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-aspartate + 2-oxoglutarate | - |
Mus musculus | oxaloacetate + L-glutamate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aspartate aminotransferase | - |
Mus musculus |
| cAST | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | decreased enzyme activity induces calpain activation by increasing the cytosolic Ca2+ concentrations of BV2 microglia, resulting in mitochondrial depolarization and cell death | Mus musculus |
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Release 2023.1 (January 2023)
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