KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.34 | - |
L-aspartate | at pH 7.4 and 37°C | Mycobacterium tuberculosis | |
29.4 | - |
kynurenine | at pH 7.4 and 37°C | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate + 2-oxoglutarate | Mycobacterium tuberculosis | - |
oxaloacetate + L-glutamate | - |
? | |
L-aspartate + 2-oxoglutarate | Mycobacterium tuberculosis H37Rv | - |
oxaloacetate + L-glutamate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | O69689 | - |
- |
Mycobacterium tuberculosis H37Rv | O69689 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
kynurenine + 2-oxoglutarate | - |
Mycobacterium tuberculosis | ? | - |
? | |
kynurenine + 2-oxoglutarate | - |
Mycobacterium tuberculosis H37Rv | ? | - |
? | |
L-aspartate + 2-oxoglutarate | - |
Mycobacterium tuberculosis | oxaloacetate + L-glutamate | - |
? | |
L-aspartate + 2-oxoglutarate | - |
Mycobacterium tuberculosis H37Rv | oxaloacetate + L-glutamate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aspartate aminotransferase | - |
Mycobacterium tuberculosis |
AspAT | - |
Mycobacterium tuberculosis |
Rv3722c | - |
Mycobacterium tuberculosis |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
136 | - |
L-aspartate | at pH 7.4 and 37°C | Mycobacterium tuberculosis | |
198 | - |
kynurenine | at pH 7.4 and 37°C | Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme deficiency leads to virulence attenuation in macrophages and mice | Mycobacterium tuberculosis |
physiological function | the enzyme is essential for virulence in macrophages and mice | Mycobacterium tuberculosis |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
6.73 | - |
kynurenine | at pH 7.4 and 37°C | Mycobacterium tuberculosis | |
58.3 | - |
L-aspartate | at pH 7.4 and 37°C | Mycobacterium tuberculosis |