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Literature summary for 2.5.1.92 extracted from

  • Samori, P.Y.; Makabe, K.; Ohya, N.; Hatano, B.; Murakami, S.; Kijima, T.
    Role of Cys73 in the thermostability of farnesyl diphosphate synthase from Geobacillus stearothermophilus (2017), 3 Biotech, 7, 236 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Geobacillus stearothermophilus

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting-drop vapor diffusion method, the crystal structure is determined at 2.31 A resolution. The structure of GsFPPase shows a three-layered all alpha-helical fold and conserved functional domains similar to other prenyltransferases Geobacillus stearothermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dimethylallyl diphosphate + 2 isopentenyl diphosphate Geobacillus stearothermophilus the product farnesyl diphosphate is an important precursor in the isoprenoid synthesis pathway 2 diphosphate + (2Z,6Z)-farnesyl diphosphate
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Organism

Organism UniProt Comment Textmining
Geobacillus stearothermophilus
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-
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Purification (Commentary)

Purification (Comment) Organism
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 Geobacillus stearothermophilus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dimethylallyl diphosphate + 2 isopentenyl diphosphate
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 Geobacillus stearothermophilus 2 diphosphate + (2Z,6Z)-farnesyl diphosphate
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 ?
dimethylallyl diphosphate + 2 isopentenyl diphosphate the product farnesyl diphosphate is an important precursor in the isoprenoid synthesis pathway Geobacillus stearothermophilus 2 diphosphate + (2Z,6Z)-farnesyl diphosphate
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 ?

Synonyms

Synonyms Comment Organism
FPPase
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 Geobacillus stearothermophilus