Literature summary for 2.5.1.90 extracted from

Inokoshi, J.; Nakamura, Y.; Komada, S.; Komatsu, K.; Umeyama, H.; Tomoda, H.
Inhibition of bacterial undecaprenyl pyrophosphate synthase by small fungal molecules (2016), J. Antibiot., 69, 798-805 .

Search for more literature for 2.5.1.90

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Escherichia coli

Inhibitors

Inhibitors	Comment	Organism	Structure
spirohexaline	-	Escherichia coli
viridicatumtoxin	-	Escherichia coli

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	0.5 mM used in assay conditions	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate	Escherichia coli	-	5 diphosphate + all-trans-octaprenyl diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Escherichia coli

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate	-	Escherichia coli	5 diphosphate + all-trans-octaprenyl diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
octaprenyl pyrophosphate synthase	-	Escherichia coli
OPP synthase	-	Escherichia coli

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0164	-	at pH 7.5 and 37°C	Escherichia coli	viridicatumtoxin
0.0646	-	at pH 7.5 and 37°C	Escherichia coli	spirohexaline

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Release 2023.1 (January 2023)