Literature summary for 2.5.1.9 extracted from

Zhang, Y.; Illarionov, B.; Morgunova, E.; Jin, G.; Bacher, A.; Fischer, M.; Ladenstein, R.; Cushman, M.
A new series of N-[2,4-dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase: design, synthesis, biochemical evaluation, crystallography, and mechanistic implications (2008), J. Org. Chem., 73, 2715-2724.

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Inhibitors

Inhibitors	Comment	Organism	Structure
N-6-(ribitylamino)pyrimidine-2,4(1H,3H)-dion-5-ylpropionamide	uncompetitive	Escherichia coli
N-6-(ribitylamino)pyrimidine-2,4(1H,3H)-dione-5-ylisobutyramide	uncompetitive	Escherichia coli
N-[2,4-dioxo-6-(ribitylamino)-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid ethyl ester	mixed type inhibition	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000013	-	pH 7.0, 27°C	Escherichia coli	N-[2,4-dioxo-6-(ribitylamino)-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid ethyl ester

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Release 2023.1 (January 2023)