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Literature summary for 2.5.1.9 extracted from
- Photolumazines, new naturally occurring inhibitors of riboflavin synthetase (1973), Biochim. Biophys. Acta, 313, 229-234.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 6-Methyl-7-hydroxy-8-ribityllumazine | - |
Eremothecium ashbyi |  |
| 7-hydroxy-6-(2-carboxyethyl)-8-(1-D-ribityl)lumazine | - |
Eremothecium ashbyi | |
| 7-hydroxy-6-(D-1,2-dihydroxyethyl)-8-(1-D-ribityl)lumazine | - |
Eremothecium ashbyi | |
| 7-Hydroxy-6-(L-1,2-dihydroxyethyl)-8-(1-D-ribityl)lumazine | i.e. photolumazine A | Eremothecium ashbyi | |
| 7-hydroxy-6-(p-hydroxyphenyl)-8-(1-D-ribityl)lumazine | - |
Eremothecium ashbyi | |
| 7-Hydroxy-6-hydroxymethyl-8-(1-D-ribityl)lumazine | photolumazine B | Eremothecium ashbyi | |
| 7-Hydroxy-8-(1-D-ribityl)lumazine | i.e. photolumazine | Eremothecium ashbyi | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6,7-dimethyl-8-ribityllumazine + 6,7-dimethyl-8-ribityllumazine | Eremothecium ashbyi | - |
riboflavin + 4-(1'-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Eremothecium ashbyi | - |
purified enzyme | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Eremothecium ashbyi |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6,7-dimethyl-8-ribityllumazine + 6,7-dimethyl-8-ribityllumazine | - |
Eremothecium ashbyi | riboflavin + 4-(1'-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0029 | - |
6-Methyl-7-hydroxy-8-ribityllumazine | - |
Eremothecium ashbyi | |
| 0.003 | - |
7-Hydroxy-6-hydroxymethyl-8-(1-D-ribityl)lumazine | - |
Eremothecium ashbyi | |
| 0.011 | - |
7-Hydroxy-8-(1-D-ribityl)lumazine | - |
Eremothecium ashbyi | |
| 0.017 | - |
7-Hydroxy-6-(L-1,2-dihydroxyethyl)-8-(1-D-ribityl)lumazine | - |
Eremothecium ashbyi | |
| 0.017 | - |
7-hydroxy-6-(D-1,2-dihydroxyethyl)-8-(1-D-ribityl)lumazine | - |
Eremothecium ashbyi | |
| 0.027 | - |
7-hydroxy-6-(2-carboxyethyl)-8-(1-D-ribityl)lumazine | - |
Eremothecium ashbyi | |
| 0.028 | - |
7-hydroxy-6-(p-hydroxyphenyl)-8-(1-D-ribityl)lumazine | - |
Eremothecium ashbyi | |
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