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Literature summary for 2.5.1.84 extracted from

  • Gotoh, T.; Koyama, T.; Ogura, K.
    Farnesyl diphosphate synthase and solanesyl diphosphate synthase reactions of diphosphate-modified allylic analogs: the significance of the diphosphate linkage involved in the allylic substrates for prenyltransferase (1992), J. Biochem., 112, 20-27.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
farnesyl methylenediphosphate above 0.005 mM Micrococcus luteus
farnesyl phosphosulfate above 0.1 mM Micrococcus luteus
Imidodiphosphate
-
Micrococcus luteus
Methylenediphosphonate
-
Micrococcus luteus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
all-trans-farnesyl methylenediphosphonate pH 7.4, 37°C Micrococcus luteus
0.0043
-
geranyl diphosphate pH 7.4, 37°C Micrococcus luteus
0.0052
-
farnesyl diphosphate pH 7.4, 37°C Micrococcus luteus
0.0054
-
Geranyl methylenediphosphonate pH 7.4, 37°C Micrococcus luteus
0.0057
-
Farnesyl imidodiphosphate pH 7.4, 37°C Micrococcus luteus
0.0077
-
Geranyl imidodiphosphate pH 7.4, 37°C Micrococcus luteus
0.0133
-
farnesyl phosphosulfate pH 7.4, 37°C Micrococcus luteus
0.0909
-
Geranyl phosphosulfate pH 7.4, 37°C Micrococcus luteus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ stimulates activity Micrococcus luteus

Organism

Organism UniProt Comment Textmining
Micrococcus luteus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans-farnesyl diphosphate + 6 isopentenyl diphosphate
-
Micrococcus luteus 6 diphosphate + all-trans-nonaprenyl diphosphate
-
?
all-trans-farnesyl methylenediphosphonate + isopentenyl diphosphate
-
Micrococcus luteus ?
-
?
farnesyl diphosphate + 6 isopentenyl diphosphate
-
Micrococcus luteus 6 diphosphate + all-trans-nonaprenyl diphosphate
-
?
farnesyl imidodiphosphate + isopentenyl diphosphate
-
Micrococcus luteus ?
-
?
farnesyl methylenediphosphonate + isopentenyl diphosphate
-
Micrococcus luteus ?
-
?
farnesyl phosphosulfate + isopentenyl diphosphate
-
Micrococcus luteus ?
-
?
geranyl diphosphate + isopentenyl diphosphate
-
Micrococcus luteus ?
-
?
geranyl imidodiphosphate + isopentenyl diphosphate
-
Micrococcus luteus ?
-
?
geranyl methylenediphosphonate + isopentenyl diphosphate
-
Micrococcus luteus ?
-
?
geranyl phosphosulfate + isopentenyl diphosphate
-
Micrococcus luteus ?
-
?
additional information no activity with geranyl phosphate or dimethylallyl phosphate Micrococcus luteus ?
-
?

Synonyms

Synonyms Comment Organism
SPP synthase
-
Micrococcus luteus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Micrococcus luteus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Micrococcus luteus