Cloned (Comment) | Organism |
---|---|
recombinant enzyme overexpression | Aspergillus fumigatus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dimethylallyl diphosphate + L-tryptophan | Aspergillus fumigatus | - |
diphosphate + 7-(3-methylbut-2-enyl)-L-tryptophan | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus fumigatus | Q4WYG3 | gene 7-DMATS | - |
Purification (Comment) | Organism |
---|---|
recombinant enzyme | Aspergillus fumigatus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-pentenyl diphosphate + L-tryptophan | C-5 prenylation | Aspergillus fumigatus | diphosphate + 5-(pent-2-enyl)-L-tryptophan | - |
? | |
benzyl diphosphate + L-tryptophan | C-5 prenylation | Aspergillus fumigatus | diphosphate + 5-benzyl-L-tryptophan | - |
? | |
dimethylallyl diphosphate + 1-methyl-DL-tryptophan | - |
Aspergillus fumigatus | diphosphate + 1-methyl-4-(3-methylbut-2-enyl)-DL-tryptophan | - |
? | |
dimethylallyl diphosphate + 11-methyl-DL-tryptophan | - |
Aspergillus fumigatus | diphosphate + 11-methyl-4-(3-methylbut-2-enyl)-DL-tryptophan | - |
? | |
dimethylallyl diphosphate + 3-iodo-L-tyrosine | C-4 prenylation | Aspergillus fumigatus | diphosphate + 3-iodo-4-(3-methylbut-2-enyl)-L-tyrosine | - |
? | |
dimethylallyl diphosphate + 4-amino-L-phenylalanine | C-4 prenylation | Aspergillus fumigatus | diphosphate + 4-amino-3-(3-methylbut-2-enyl)-L-phenylalanine | - |
? | |
dimethylallyl diphosphate + 4-methyl-DL-tryptophan | - |
Aspergillus fumigatus | diphosphate + 4-methyl-7-(3-methylbut-2-enyl)-DL-tryptophan | - |
? | |
dimethylallyl diphosphate + 5-bromo-L-tryptophan | low activity | Aspergillus fumigatus | diphosphate + 5-bromo-4-(3-methylbut-2-enyl)-L-tryptophan | - |
? | |
dimethylallyl diphosphate + 5-hydroxy-L-tryptophan | - |
Aspergillus fumigatus | diphosphate + 5-hydroxy-4-(3-methylbut-2-enyl)-L-tryptophan | - |
? | |
dimethylallyl diphosphate + 5-methyl-DL-tryptophan | - |
Aspergillus fumigatus | diphosphate + 5-methyl-4-(3-methylbut-2-enyl)-DL-tryptophan | - |
? | |
dimethylallyl diphosphate + 6-fluoro-DL-tryptophan | - |
Aspergillus fumigatus | diphosphate + 6-fluoro-4-(3-methylbut-2-enyl)-DL-tryptophan | - |
? | |
dimethylallyl diphosphate + 6-methyl-DL-tryptophan | low activity | Aspergillus fumigatus | diphosphate + 6-methyl-4-(3-methylbut-2-enyl)-DL-tryptophan | - |
? | |
dimethylallyl diphosphate + beta-homo-L-tryptophan | - |
Aspergillus fumigatus | ? | - |
? | |
dimethylallyl diphosphate + D-tryptophan | low activity | Aspergillus fumigatus | diphosphate + 4-(3-methylbut-2-enyl)-D-tryptophan | - |
? | |
dimethylallyl diphosphate + DL-indole-3-lactic acid | - |
Aspergillus fumigatus | ? | - |
? | |
dimethylallyl diphosphate + indole-3-propionic acid | - |
Aspergillus fumigatus | ? | - |
? | |
dimethylallyl diphosphate + L-abrine | - |
Aspergillus fumigatus | ? | - |
? | |
dimethylallyl diphosphate + L-o-tyrosine | C-4 prenylation | Aspergillus fumigatus | diphosphate + 4-(3-methylbut-2-enyl)-L-o-tyrosine | 4-dimethylallyl-L-o-tyrosine | ? | |
dimethylallyl diphosphate + L-tryptophan | - |
Aspergillus fumigatus | diphosphate + 7-(3-methylbut-2-enyl)-L-tryptophan | - |
? | |
dimethylallyl diphosphate + N-acetyl-DL-tryptophan | - |
Aspergillus fumigatus | diphosphate + N-acetyl-4-(3-methylbut-2-enyl)-DL-tryptophan | - |
? | |
methylallyl diphosphate + L-tryptophan | C-4 and C-5 prenylation | Aspergillus fumigatus | diphosphate + 4-(but-2-enyl)-L-tryptophan | - |
? | |
methylallyl diphosphate + L-tryptophan | C-4 and C-5 prenylation | Aspergillus fumigatus | diphosphate + 5-(but-2-enyl)-L-tryptophan | - |
? | |
additional information | no activity with 7-methyl-DL-tryptophan, alpha-methyl-L-tyrosine, L-m-tyrosine, and D-tyrosine. The enzyme is also active with hydroxynaphthalenes which it prenylates at C-4 or C-1, overview | Aspergillus fumigatus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
7-DMATS | - |
Aspergillus fumigatus |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme is part of the DMATS superfamily | Aspergillus fumigatus |