Literature summary for 2.5.1.7 extracted from

Kumar, A.; Saranathan, R.; Prashanth, K.; Tiwary, B.K.; Krishna, R.
Inhibition of the MurA enzyme in Fusobacterium nucleatum by potential inhibitors identified through computational and in vitro approaches (2017), Mol. Biosyst., 13, 939-954 .

Search for more literature for 2.5.1.7

Cloned(Commentary)

Cloned (Comment)	Organism
-	Fusobacterium nucleatum subsp. nucleatum

Inhibitors

Inhibitors	Comment	Organism	Structure
fosfomycin	-	Fusobacterium nucleatum subsp. nucleatum
additional information	inhibitors are identified through computational and in vitro approaches	Fusobacterium nucleatum subsp. nucleatum
orientin	mixed type inhibition	Fusobacterium nucleatum subsp. nucleatum
quercetin-3-O-D-glucuronide	uncompetitive inhibition	Fusobacterium nucleatum subsp. nucleatum
T6361	-	Fusobacterium nucleatum subsp. nucleatum

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.077	-	phosphoenolpyruvate	pH 7.5, 37°C	Fusobacterium nucleatum subsp. nucleatum
0.18	-	UDP-N-acetyl-alpha-D-glucosamine	pH 7.5, 37°C	Fusobacterium nucleatum subsp. nucleatum

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
48000	-	SDS-PAGE	Fusobacterium nucleatum subsp. nucleatum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine	Fusobacterium nucleatum subsp. nucleatum	-	phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine	-	?
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine	Fusobacterium nucleatum subsp. nucleatum ATCC 25586	-	phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine	-	?

Organism

Organism	UniProt	Comment	Textmining
Fusobacterium nucleatum subsp. nucleatum	Q8RIQ1	-	-
Fusobacterium nucleatum subsp. nucleatum ATCC 25586	Q8RIQ1	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Fusobacterium nucleatum subsp. nucleatum

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine	-	Fusobacterium nucleatum subsp. nucleatum	phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine	-	?
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine	-	Fusobacterium nucleatum subsp. nucleatum ATCC 25586	phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine	-	?

Subunits

Subunits	Comment	Organism
?	x * 48000, SDS-PAGE	Fusobacterium nucleatum subsp. nucleatum

Synonyms

Synonyms	Comment	Organism
MurA	-	Fusobacterium nucleatum subsp. nucleatum

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00953	-	quercetin-3-O-D-glucuronide	pH 7.5, 37°C	Fusobacterium nucleatum subsp. nucleatum
0.05109	-	orientin	pH 7.5, 37°C	Fusobacterium nucleatum subsp. nucleatum

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Release 2023.1 (January 2023)