Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine | Acinetobacter baumannii | the enzyme catalyzes the first committed step of peptidoglycan biosynthesis | phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine | - |
? |
Organic Solvent | Comment | Organism |
---|---|---|
urea | the urea-induced unfolding of the enzyme is a three-state process, where a metastable intermediate conformation state is populated between 3.0-4.0 M. Above 6.0 M urea, the enzyme gets completely unfolded. The transition from the native structure to the partially unfolded metastable state involves about 30% loss of native contacts but little change in the radius of gyration or core hydration properties. The intermediate-to-unfolded state transition is characterized by a large increase in the radius of gyration. Molecular dynamics trajectories simulated in different unfolding conditions suggest that urea destabilizes the enzyme structure weakening hydrophobic interactions and the hydrogen bond network | Acinetobacter baumannii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Acinetobacter baumannii | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Acinetobacter baumannii |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine | - |
Acinetobacter baumannii | phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine | - |
? | |
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine | the enzyme catalyzes the first committed step of peptidoglycan biosynthesis | Acinetobacter baumannii | phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MurA | - |
Acinetobacter baumannii |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme catalyzes the first committed step of peptidoglycan biosynthesis | Acinetobacter baumannii |