Literature summary for 2.5.1.7 extracted from

Boulhissa, I.; Chikhi, A.; Bensegueni, A.; Ghattas, M.A.; Mokrani, E.H.; Alrawashdeh, S.; Eddin Obaid, D.E.
Investigation for new inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) by virtual screening with antibacterial sssessment (2020), Curr. Comput. Aided Drug Des., 17, 214-224.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(hydroxymethyl)phosphonic acid	i.e. CID-21680357	Escherichia coli
fosfomycin	acting competitively as an analogue of phosphoenolpyruvate	Escherichia coli
oxalic acid	i.e. AB-00005001	Escherichia coli
oxamic acid	i.e. ZINC04658565	Escherichia coli
Tartronic acid	i.e. ZINC901335	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine	Escherichia coli	-	phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine	-	?
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine	Escherichia coli K12	-	phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0A749	-	-
Escherichia coli K12	P0A749	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine	-	Escherichia coli	phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine	-	?
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine	-	Escherichia coli K12	phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine	-	?

Synonyms

Synonyms	Comment	Organism
MurA	-	Escherichia coli

General Information

General Information	Comment	Organism
metabolism	the enzyme catalyzes the first step of peptidoglycan biosynthesis pathway which is essential in the bacterial cell wall composition	Escherichia coli
physiological function	the enzyme catalyzes the first step of peptidoglycan biosynthesis pathway which is essential in the bacterial cell wall composition	Escherichia coli

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Release 2023.1 (January 2023)