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Literature summary for 2.5.1.7 extracted from

  • Lima, A.H.; Dos Santos, A.M.; Alves, C.N.; Lameira, J.
    Computed insight into a peptide inhibitor preventing the induced fit mechanism of MurA enzyme from Pseudomonas aeruginosa (2017), Chem. Biol. Drug Des., 89, 599-607 .
    View publication on PubMed
Search for more literature for 2.5.1.7

Inhibitors

Inhibitors Comment Organism Structure
HESFWYLPHQSY i.e. PEP 1354. the peptide seems to prevent the closure of the Pro114-123 loop and, consequently, the open-closed transition of the MurA structure Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine Pseudomonas aeruginosa
-
 phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine
-
 Pseudomonas aeruginosa phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
-
 ?

Synonyms

Synonyms Comment Organism
MurA enzyme
-
 Pseudomonas aeruginosa
UDP-N-acetylglucosamine enolpyruvyl transferase
-
 Pseudomonas aeruginosa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.2
-
 pH and temperature not specified in the publication Pseudomonas aeruginosa HESFWYLPHQSY

General Information

General Information Comment Organism
physiological function one of the key enzymes involved in peptidoglycan biosynthesis Pseudomonas aeruginosa