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Literature summary for 2.5.1.7 extracted from

  • Eschenburg, S.; Priestman, M.A.; Abdul-Latif, F.A.; Delachaume, C.; Fassy, F.; Schonbrunn, E.
    A novel inhibitor that suspends the induced fit mechanism of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) (2005), J. Biol. Chem., 280, 14070-14075.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with inhibitor T6361 Enterobacter cloacae

Inhibitors

Inhibitors Comment Organism Structure
(S)-2-[2-(naphthalene-1-sulfonylamino)-5-(naphthalene-1-sulfonyloxy)-benzoylamino]-pentanedioic acid competitive with UDP-N-acetylglucosamine Enterobacter cloacae
(S)-2-[2-(naphthalene-1-sulfonylamino)-5-(naphthalene-1-sulfonyloxy)-benzoylamino]-succinic acid
-
Enterobacter cloacae
additional information inhibitors derived from 5-sulfonoxy-anthranilic acid obstruct the transition from the open and unliganded to the closed UDP-N-acetylglucosamine liganded form Enterobacter cloacae
T6362
-
Enterobacter cloacae

Organism

Organism UniProt Comment Textmining
Enterobacter cloacae P33038
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.016
-
T6362 20°C, pH 8.0 Enterobacter cloacae