Protein Variants | Comment | Organism |
---|---|---|
K22E | 0.05% of wild-type activity, no formation of covalent adduct with fosfomycin | Enterobacter cloacae |
K22R | 0.3% of wild-type activity | Enterobacter cloacae |
K22V | 0.03% of wild-type activity, similar to wild-type in binding of fosfomycin, presence of UDP-N-acetylglucosamine required | Enterobacter cloacae |
K22V/R120K | no residual activity, heat capacity changes are markedly redcued | Enterobacter cloacae |
K22V/R120V | no residual activity | Enterobacter cloacae |
R120K | less than 0.05% of wild-type activity, heat capacity changes are markedly redcued | Enterobacter cloacae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fosfomycin | irreversible, alkylation of C115 | Enterobacter cloacae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Enterobacter cloacae | P33038 | - |
- |