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Literature summary for 2.5.1.7 extracted from

  • McCoy, A.J.; Sandlin, R.C.; Maurelli, A.T.
    In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance (2003), J. Bacteriol., 185, 1218-1228.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.7

Application

Application Comment Organism
medicine target for development of antibacterial agents Chlamydia trachomatis

Cloned(Commentary)

Cloned (Comment) Organism
gene murA, DNA sequence analysis, expression in Escherichia coli under control of the arabinose-inducible, glucose-repressible ara promotor, functional complementation, necessary for viability, of a enzyme-deficient Escherichia coli murA null-mutant, impartment of fosfomycin resistance to the Escherichia coli cell Chlamydia trachomatis

Inhibitors

Inhibitors Comment Organism Structure
fosfomycin resistant to fosfomycin inhibition due to exchange of cysteine for aspartate in the active site Chlamydia trachomatis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine Chlamydia trachomatis peptidoglycan formation is essential for progression through the developmental cycle as well as for cell division phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
-
 ?
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine Chlamydia trachomatis MurA peptidoglycan formation is essential for progression through the developmental cycle as well as for cell division phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
-
 ?

Organism

Organism UniProt Comment Textmining
Chlamydia trachomatis
-
 MurA
-
Chlamydia trachomatis
-
 gene murA
-
Chlamydia trachomatis
-
 serovar L2
-
Chlamydia trachomatis MurA
-
 MurA
-

Reaction

Reaction Comment Organism Reaction ID
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine exchange of cysteine to aspartate in the active site Chlamydia trachomatis
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine
-
 Chlamydia trachomatis phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
-
 ?
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine peptidoglycan formation is essential for progression through the developmental cycle as well as for cell division Chlamydia trachomatis phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
-
 ?
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine
-
 Chlamydia trachomatis MurA phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
-
 ?
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine peptidoglycan formation is essential for progression through the developmental cycle as well as for cell division Chlamydia trachomatis MurA phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
-
 ?