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Literature summary for 2.5.1.7 extracted from

  • Kim, D.H.; Lees, W.J.; Walsh, C.T.
    Stereochemical analysis of the tetrahedral adduct formed at the active site of UDP-GlcNAc enolpyruvyl transferase from the pseudosubstrates, (E)- and (Z)-3-fluorophosphoenolpyruvate, in D2O (1995), J. Am. Chem. Soc., 117, 6380-6381.
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Search for more literature for 2.5.1.7

Inhibitors

Inhibitors Comment Organism Structure
(E)-3-fluorophosphoenolpyruvate pseudosubstrate, formation of a tetrahedral intermediate in the reaction pathway, investigation of chirality of the intermediate stereospecifically formed at the active site in D2O Escherichia coli
(Z)-3-fluorophosphoenolpyruvate pseudosubstrate, formation of a tetrahedral intermediate in the reaction pathway, investigation of chirality of the intermediate stereospecifically formed at the active site in D2O Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 MurZ
-
Escherichia coli MurZ
-
 MurZ
-

Reaction

Reaction Comment Organism Reaction ID
phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine the addition step proceeds with protonation of C-3 of phosphoenolpyruvate from the 2-si face Escherichia coli
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine
-
 Escherichia coli phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
-
 ?
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine
-
 Escherichia coli MurZ phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
-
 ?

Synonyms

Synonyms Comment Organism
UDP-GlcNAc enolpyruvyl transferase
-
 Escherichia coli