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Literature summary for 2.5.1.68 extracted from

  • Nagaki, M.; Ichijo, T.; Kobashi, R.; Yagihashi, Y.; Musashi, T.; Kawakami, J.; Ohya, N.; Gotoh, T.; Sagami, H.
    Substrate specificities of E- and Z-farnesyl diphosphate synthases with substrate analogs (2012), J. Mol. Catal. B, 80, 1-6.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Thermobifida fusca

Organism

Organism UniProt Comment Textmining
Thermobifida fusca Q47SS3
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Purification (Commentary)

Purification (Comment) Organism
His Trap column chromatography Thermobifida fusca

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
8-hydroxygeranyl diphosphate + isopentenyl diphosphate
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Thermobifida fusca (2Z)-12-hydroxyfarnesyl diphosphate + (2Z, 6Z)-16-hydroxygeranylgeranyl diphosphate + diphosphate 16.7% yield of (2Z)-12-hydroxyfarnesyl diphosphate, 6.6% yield of (2Z, 6Z)-16-hydroxygeranylgeranyl diphosphate ?
additional information the enzyme does not catalyze reactions between 8-tetrahydropyran-2-yloxygeranyl diphosphate and isopentenyl diphosphate Thermobifida fusca ?
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?

Synonyms

Synonyms Comment Organism
Z-farnesyl diphosphate synthase
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Thermobifida fusca
Z-FPP synthase
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Thermobifida fusca