Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.68 extracted from

  • Crick, D.C.; Schulbach, M.C.; Zink, E.E.; Macchia, M.; Barontini, S.; Besra, G.S.; Brennan, P.J.
    Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis (2000), J. Bacteriol., 182, 5771-5778.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.68

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol major activity Mycolicibacterium smegmatis 5829
-
cytosol major activity Mycobacterium tuberculosis 5829
-
membrane minor activity Mycolicibacterium smegmatis 16020
-
membrane minor activity Mycobacterium tuberculosis 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Mycolicibacterium smegmatis
Mg2+ activates Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geranyl diphosphate + isopentenyl diphosphate Mycolicibacterium smegmatis step in polyprenylphosphate biosynthesis, overview (2Z,6E)-farnesyl diphosphate + diphosphate
-
 ?
geranyl diphosphate + isopentenyl diphosphate Mycobacterium tuberculosis step in polyprenylphosphate biosynthesis, overview (2Z,6E)-farnesyl diphosphate + diphosphate
-
 ?
geranyl diphosphate + isopentenyl diphosphate Mycobacterium tuberculosis H37Rv step in polyprenylphosphate biosynthesis, overview (2Z,6E)-farnesyl diphosphate + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-
Mycolicibacterium smegmatis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranyl diphosphate + isopentenyl diphosphate stereospecific reaction Mycolicibacterium smegmatis (2Z,6E)-farnesyl diphosphate + diphosphate i.e. omega,E,Z-farnesyl diphosphate ?
geranyl diphosphate + isopentenyl diphosphate stereospecific reaction Mycobacterium tuberculosis (2Z,6E)-farnesyl diphosphate + diphosphate i.e. omega,E,Z-farnesyl diphosphate ?
geranyl diphosphate + isopentenyl diphosphate step in polyprenylphosphate biosynthesis, overview Mycolicibacterium smegmatis (2Z,6E)-farnesyl diphosphate + diphosphate
-
 ?
geranyl diphosphate + isopentenyl diphosphate step in polyprenylphosphate biosynthesis, overview Mycobacterium tuberculosis (2Z,6E)-farnesyl diphosphate + diphosphate
-
 ?
geranyl diphosphate + isopentenyl diphosphate stereospecific reaction Mycobacterium tuberculosis H37Rv (2Z,6E)-farnesyl diphosphate + diphosphate i.e. omega,E,Z-farnesyl diphosphate ?
geranyl diphosphate + isopentenyl diphosphate step in polyprenylphosphate biosynthesis, overview Mycobacterium tuberculosis H37Rv (2Z,6E)-farnesyl diphosphate + diphosphate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mycolicibacterium smegmatis
37
-
 assay at Mycobacterium tuberculosis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.9
-
 assay at Mycolicibacterium smegmatis
7.9
-
 assay at Mycobacterium tuberculosis