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Literature summary for 2.5.1.67 extracted from

  • Thulasiram, H.V.; Erickson, H.K.; Poulter, C.D.
    A common mechanism for branching, cyclopropanation, and cyclobutanation reactions in the isoprenoid biosynthetic pathway (2008), J. Am. Chem. Soc., 130, 1966-1971.
    View publication on PubMed
Search for more literature for 2.5.1.67

Cloned(Commentary)

Cloned (Comment) Organism
a c98f chimera is constructed by replacing the first 98 residues in Artemisia tridentata subsp. spiciformis farnesyl diphosphate synthase with the corresponding sequence from chrysanthemyl diphosphate synthase, the enzymes are cloned in Escherichia coli hosts Artemisia spiciformis

Metals/Ions

Metals/Ions Comment Organism Structure
MgCl2 10 mM are included in assay medium Artemisia spiciformis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6 dimethylallyl diphosphate Artemisia spiciformis
-
 (R)-lavandulyl diphosphate + (R)-maconelliyl diphosphate + (1R,3R)-chyrsanthemyl diphosphate + 3 diphosphate non-head-to-tail alcohols after incubation of dimethylallyl diphosphate with CPP synthase followed by hydrolysis with alkaline phosphatase ?

Organism

Organism UniProt Comment Textmining
Artemisia spiciformis Q7XYS8
-
-
Artemisia spiciformis Q7XYS8 subsp. spiciformis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 dimethylallyl diphosphate
-
 Artemisia spiciformis diphosphate + chrysanthemyl diphosphate
-
 ?
6 dimethylallyl diphosphate
-
 Artemisia spiciformis (R)-lavandulyl diphosphate + (R)-maconelliyl diphosphate + (1R,3R)-chyrsanthemyl diphosphate + 3 diphosphate non-head-to-tail alcohols after incubation of dimethylallyl diphosphate with CPP synthase followed by hydrolysis with alkaline phosphatase ?

Synonyms

Synonyms Comment Organism
chrysanthemyl diphosphate synthase
-
 Artemisia spiciformis
CPP synthase
-
 Artemisia spiciformis
CPPase
-
 Artemisia spiciformis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Artemisia spiciformis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 assay at Artemisia spiciformis

General Information

General Information Comment Organism
physiological function biosynthesis of isoprenoid compounds Artemisia spiciformis