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Literature summary for 2.5.1.66 extracted from

  • Kwong, T.; Tahlan, K.; Anders, C.L.; Jensen, S.E.
    Carboxyethylarginine synthase genes show complex cross-regulation in Streptomyces clavuligerus (2013), Appl. Environ. Microbiol., 79, 240-249.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Streptomyces clavuligerus E2Q5Q8 isoform ceaS2
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Streptomyces clavuligerus Q6TA05 isoform CeaS1
-

Synonyms

Synonyms Comment Organism
CeaS1
-
 Streptomyces clavuligerus
ceaS2
-
 Streptomyces clavuligerus

Expression

Organism Comment Expression
Streptomyces clavuligerus transcription of isoform ceaS1 is reduced or abolished in isoform ceaS2 mutants grown in liquid soy medium, despite the location of ceaS1 on a replicon completely separate from that of ceaS2. In addition, the CeaS1 protein as well as the CeaS2 protein is absent from the ceaS2 mutants. When the mutants are grown on solid soy medium, clavam production is restored and CeaS1 is produced, albeit at low levels compared to the wild type down
Streptomyces clavuligerus transcription of isoform ceaS1 is reduced or abolished in isoform ceaS2 mutants grown in liquid soy, despite the location of ceaS1 on a replicon completely separate from that of ceaS2. In addition, the CeaS1 protein as well as the CeaS2 protein is absent from the ceaS2 mutants. When the mutants are grown on solid soy medium, clavam production is restored and CeaS1 is produced, albeit at low levels compared to the wild type down

General Information

General Information Comment Organism
physiological function deletion of the gene encoding isoform ceaS1 results in complete loss of clavam biosynthesis when grown in liquid soy medium. The failure to produce clavam metabolites is due to reduced or abolished transcription of isoform ceaS1 in the ceaS2 mutants. When the same mutants are grown on solid soy medium, clavam production is restored and ceaS1 is produced, albeit at low levels compared to the wild-type Streptomyces clavuligerus
physiological function deletion of the gene encoding isoform CeaS1 results in mild reduction of clavam biosynthesis when grown in liquid soy medium Streptomyces clavuligerus