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Literature summary for 2.5.1.66 extracted from
- The paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerus (2004), J. Bacteriol., 186, 6286-6297.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | analysis of the nutritional regulation of ceaS1 and ceaS2 expression, ceaS1 is transcribed in complex soy medium only, whereas ceaS2 is transcribed in both soy and defined starch-asparagine media | Streptomyces clavuligerus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| ceaS1 and ceaS2, ceaS2 is located in the clavulanic acid gene cluster, ceaS1 in the paralogue gene cluster, study of the transcriptional regulation of the genes | Streptomyces clavuligerus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Streptomyces clavuligerus | CEAS catalyzes the first reaction in the shared biosynthetic pathway leading to clavulanic acid and 5S clavams, ceaS1 and ceaS2 genes are regulated by different mechanisms, ceaS1 may be more closely associated with the production of 5S clavams via a CcaR-independent pathway, whereas ceaS2 is associated with clavulanic acid production and is regulated by the transcriptional activator CcaR | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces clavuligerus | - |
wild-type strain NRRL3585, two paralogous genes ceaS1 and ceaS2 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glyceraldehyde 3-phosphate + L-arginine | - |
Streptomyces clavuligerus | N2-(2-carboxyethyl)-L-arginine + phosphate | - |
? | |
| additional information | CEAS catalyzes the first reaction in the shared biosynthetic pathway leading to clavulanic acid and 5S clavams, ceaS1 and ceaS2 genes are regulated by different mechanisms, ceaS1 may be more closely associated with the production of 5S clavams via a CcaR-independent pathway, whereas ceaS2 is associated with clavulanic acid production and is regulated by the transcriptional activator CcaR | Streptomyces clavuligerus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| carboxyethylarginine synthase | - |
Streptomyces clavuligerus |
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