Application | Comment | Organism |
---|---|---|
analysis | the enzyme is applied as a catalyst for the efficient incorporation of [18F]-fluoride into [18F]-59-fluoro-59-deoxyadenosine, [18F]-59-fluoro-59-deoxyinosine and [18F]-5-fluoro-5-deoxyribose for positron emission tomography, PET, applications, useful for imaging tumors, monitoring the distribution of drugs and identifying cell and receptor degeneration in the brain | Streptomyces cattleya |
synthesis | the enzyme is used in biotransformation reaction for production of fluorinated compounds, biotransformation protocols for coupled reaction systems, overview | Streptomyces cattleya |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Streptomyces cattleya | fluoroacetate and 4-fluorothreonine accumulate in the fermentation media of Streptomyces cattleya at the mM level, when a fluoride source is added to the growth medium | ? | - |
? | |
S-adenosyl-L-methionine + fluoride | Streptomyces cattleya | - |
5'-deoxy-5'-fluoroadenosine + L-methionine | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces cattleya | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine | reaction mechanism, overview | Streptomyces cattleya |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2'-deoxyadenosyl-L-methionine + fluoride | - |
Streptomyces cattleya | 2'-deoxy-5'-fluoroadenosine + L-methionine | in the reverse reaction the enzyme shows 10% activity with the 2'-deoxy compound compared to the activity with the 5'-derivative | r | |
additional information | fluoroacetate and 4-fluorothreonine accumulate in the fermentation media of Streptomyces cattleya at the mM level, when a fluoride source is added to the growth medium | Streptomyces cattleya | ? | - |
? | |
S-adenosyl-L-methionine + fluoride | - |
Streptomyces cattleya | 5'-deoxy-5'-fluoroadenosine + L-methionine | - |
r |
Subunits | Comment | Organism |
---|---|---|
hexamer | a dimer of trimers | Streptomyces cattleya |
Synonyms | Comment | Organism |
---|---|---|
5'-FDA synthase | - |
Streptomyces cattleya |
5'-fluoro-5'-deoxyadenosine synthase | - |
Streptomyces cattleya |
fluorinase | - |
Streptomyces cattleya |