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Literature summary for 2.5.1.6 extracted from

  • Ikeda, S.; Kawahara-Miki, R.; Iwata, H.; Sugimoto, M.; Kume, S.
    Role of methionine adenosyltransferase 2A in bovine preimplantation development and its associated genomic regions (2017), Sci. Rep., 7, 3800 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.6

Inhibitors

Inhibitors Comment Organism Structure
fluorinated N,N-dialkylaminostilbene-5 i.e. FIDAS Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo preimplantation embryo Bos taurus
-
oocyte
-
 Bos taurus
-

Synonyms

Synonyms Comment Organism
MAT2A
-
 Bos taurus
methionine adenosyltransferase 2A
-
 Bos taurus

Expression

Organism Comment Expression
Bos taurus immunofluorescence analysis of bovine oocytes and preimplantation embryos revealed the consistent expression of MAT2A (the catalytic subunit of the ubiquitously expressed-type of MAT isozyme) during this period up

General Information

General Information Comment Organism
malfunction addition of the methionine adenosyltransferase (MAT2A) inhibitor FIDAS to the culture media of bovine preimplantation embryos reduces their blastocyst development Bos taurus
metabolism the enzyme is involved in folate-mediated one-carbon metabolism which is essential for preimplantation embryos in terms of both short-term periconceptional development and long-term phenotypic programming beyond the periconceptional period. Particular importance of the enzyme (MAT2A) in successful blastocyst development. Critical involvement of the enzyme (MAT2A) in the periconceptional period in life-long programming of health and disease as well as successful preimplantation development Bos taurus