Literature summary for 2.5.1.6 extracted from

Meng, J.; Wang, L.; Wang, J.; Zhao, X.; Cheng, J.; Yu, W.; Jin, D.; Li, Q.; Gong, Z.
METHIONINE ADENOSYLTRANSFERASE4 mediates DNA and histone methylation (2018), Plant Physiol., 177, 652-670 .

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Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	Q9LUT2	line L119	-

Synonyms

Synonyms	Comment	Organism
(Met) adenosyltransferase 4	-	Arabidopsis thaliana
MAT4	-	Arabidopsis thaliana
methionine adenosyltransferase 4	-	Arabidopsis thaliana
S-adenosyl-Met synthetase 3	-	Arabidopsis thaliana

General Information

General Information	Comment	Organism
malfunction	mat4 mostly decreases CHG and CHH DNA methylation and histone H3K9me2 and reactivates certain silenced transposons. The exogenous addition of S-adenosyl-L-methionine partially rescues the epigenetic defects of mat4. MAT4 knockout mutations generated by CRISPR/Cas9 are lethal, indicating that MAT4 is an essential gene in Arabidopsis	Arabidopsis thaliana
metabolism	the enzyme catalyzes the synthesis of S-adenosyl-Met in the one-carbon metabolism cycle. MAT4 plays a predominant role in SAM production, plant growth, and development	Arabidopsis thaliana

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Release 2023.1 (January 2023)