Literature summary for 2.5.1.6 extracted from

Hayashi, T.; Teruya, T.; Chaleckis, R.; Morigasaki, S.; Yanagida, M.
S-Adenosylmethionine synthetase is required for cell growth, maintenance of G0 phase, and termination of quiescence in fission yeast (2018), iScience, 5, 38-51 .

Search for more literature for 2.5.1.6

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-methionine + H2O	Schizosaccharomyces pombe	-	phosphate + diphosphate + S-adenosyl-L-methionine	-	?
ATP + L-methionine + H2O	Schizosaccharomyces pombe ATCC 24843	-	phosphate + diphosphate + S-adenosyl-L-methionine	-	?

Organism

Organism	UniProt	Comment	Textmining
Schizosaccharomyces pombe	O60198	-	-
Schizosaccharomyces pombe ATCC 24843	O60198	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-methionine + H2O	-	Schizosaccharomyces pombe	phosphate + diphosphate + S-adenosyl-L-methionine	-	?
ATP + L-methionine + H2O	-	Schizosaccharomyces pombe ATCC 24843	phosphate + diphosphate + S-adenosyl-L-methionine	-	?

Synonyms

Synonyms	Comment	Organism
S-adenosylmethionine synthetase	-	Schizosaccharomyces pombe
Sam1	-	Schizosaccharomyces pombe

General Information

General Information	Comment	Organism
malfunction	sam1 mutants lose viability during nitrogen starvation-induced G0 phase quiescence. After release from the G0 state, sam1 mutants could neither increase in cell size nor re-initiate DNA replication in the rich medium	Schizosaccharomyces pombe
metabolism	the product S-adenosylmethionine serves as the methyl donor in most methyl transfer reactions, including methylation of proteins, nucleic acids, and lipids. The enzyme is required for cell growth and proliferation, and maintenance of and exit from quiescence	Schizosaccharomyces pombe

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Release 2023.1 (January 2023)