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Literature summary for 2.5.1.6 extracted from

  • Dippe, M.; Brandt, W.; Rost, H.; Porzel, A.; Schmidt, J.; Wessjohann, L.A.
    Rationally engineered variants of S-adenosylmethionine (SAM) synthase: reduced product inhibition and synthesis of artificial cofactor homologues (2015), Chem. Commun. (Camb.), 51, 3637-3640.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
I105A/I317A the conversion of the natural substrate methionine is reduced in this mutant Bacillus subtilis
I105V/I317A the conversion of the natural substrate methionine is reduced in this mutant Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-methionine + H2O Bacillus subtilis
-
phosphate + diphosphate + S-adenosyl-L-methionine
-
?
ATP + L-methionine + H2O Bacillus subtilis ATCC 6051
-
phosphate + diphosphate + S-adenosyl-L-methionine
-
?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Bacillus subtilis ATCC 6051
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D,L-methionine-(methyl-D3) + H2O
-
Bacillus subtilis ?
-
?
ATP + D,L-methionine-(methyl-D3) + H2O
-
Bacillus subtilis ATCC 6051 ?
-
?
ATP + L-methionine + H2O
-
Bacillus subtilis phosphate + diphosphate + S-adenosyl-L-methionine
-
?
ATP + L-methionine + H2O
-
Bacillus subtilis ATCC 6051 phosphate + diphosphate + S-adenosyl-L-methionine
-
?

Synonyms

Synonyms Comment Organism
S-adenosylmethionine synthase
-
Bacillus subtilis
SAM synthase
-
Bacillus subtilis
SAMS
-
Bacillus subtilis