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Literature summary for 2.5.1.6 extracted from

  • Ramani, K.; Yang, H.; Xia, M.; Ara, A.I.; Mato, J.M.; Lu, S.C.
    Leptins mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta (2008), Hepatology, 47, 521-531.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.6

Activating Compound

Activating Compound Comment Organism Structure
leptin induces the expression of MAT2A and MAT2beta Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
methylthioadenosine lowers expression of MAT2A and MAT2beta Homo sapiens
S-adenosylmethionine lowers expression of MAT2A and MAT2beta Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
hepatocarcinoma cell
-
 Homo sapiens
-
hepatocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-methionine + H2O
-
 Homo sapiens phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?

Synonyms

Synonyms Comment Organism
MAT2A part of the catalytic subunit Homo sapiens
MAT2beta regulatory subunit Homo sapiens
methionine adenosyltransferase 2A
-
 Homo sapiens
methionine adenosyltransferase 2beta
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens