Literature summary for 2.5.1.6 extracted from

Perez-Pertejo, Y.; Reguera, R.M.; Ordonez, D.; Balana-Fouce, R.
Characterization of a methionine adenosyltransferase over-expressing strain in the trypanosomatid Leishmania donovani (2006), Biochim. Biophys. Acta, 1760, 10-19.

Search for more literature for 2.5.1.6

Cloned(Commentary)

Cloned (Comment)	Organism
gene MAT-2, stable expression in Leishmania donovani promastigotes, phenotypic effects, overview	Leishmania donovani

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Leishmania donovani

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-methionine + H2O	Leishmania donovani	a post-translational mechanism is involved in MAT regulation, the enzyme is down-regulated in pathological processes such as liver cirrhosis, overview	phosphate + diphosphate + S-adenosyl-L-methionine	-	?

Organism

Organism	UniProt	Comment	Textmining
Leishmania donovani	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-methionine + H2O	-	Leishmania donovani	phosphate + diphosphate + S-adenosyl-L-methionine	-	?
ATP + L-methionine + H2O	a post-translational mechanism is involved in MAT regulation, the enzyme is down-regulated in pathological processes such as liver cirrhosis, overview	Leishmania donovani	phosphate + diphosphate + S-adenosyl-L-methionine	-	?

Synonyms

Synonyms	Comment	Organism
MAT	-	Leishmania donovani

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	assay at	Leishmania donovani

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Leishmania donovani

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Release 2023.1 (January 2023)