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Literature summary for 2.5.1.6 extracted from

  • Sufrin, J.R.; Lombardini, J.B.; Alks, V.
    Differential kinetic properties of L-2-amino-4-methylthio-cis-but-3-enoic acid, a methionine analog inhibitor of S-adenosylmethionine synthetase (1993), Biochim. Biophys. Acta, 1202, 87-91.
    View publication on PubMed
Search for more literature for 2.5.1.6

Inhibitors

Inhibitors Comment Organism Structure
L-2-Amino-4-methoxy-cis-but-3-enoic acid
-
 Mus musculus
L-2-Amino-4-methylthio-cis-but-3-enoic acid
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-methionine + H2O Mus musculus methyl donor in transmethylation reactions and as propylamine donor for polyamine biosynthesis S-adenosyl-L-methionine + phosphate + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 mouse, 2 isoenzymes: I and II
-

Purification (Commentary)

Purification (Comment) Organism
two isoenzymes: I and II Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
ascites L1210 cell line, two isoenzymes Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxy-ATP + L-methionine + H2O
-
 Mus musculus ?
-
 ?
3'-deoxy-ATP + L-methionine + H2O
-
 Mus musculus ?
-
 ?
ATP + L-methionine + H2O
-
 Mus musculus S-adenosyl-L-methionine + phosphate + diphosphate
-
 ?
ATP + L-methionine + H2O methyl donor in transmethylation reactions and as propylamine donor for polyamine biosynthesis Mus musculus S-adenosyl-L-methionine + phosphate + diphosphate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0031
-
 L-2-Amino-4-methoxy-cis-but-3-enoic acid isoenzyme II Mus musculus
0.0057
-
 L-2-Amino-4-methylthio-cis-but-3-enoic acid isoenzyme II Mus musculus
0.0063
-
 L-2-Amino-4-methoxy-cis-but-3-enoic acid isoenzyme I Mus musculus
0.021
-
 L-2-Amino-4-methylthio-cis-but-3-enoic acid isoenzyme I Mus musculus