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Literature summary for 2.5.1.6 extracted from

  • Hoffman, J.L.
    Fractionation of methionine adenosyltransferase isozymes (rat liver) (1983), Methods Enzymol., 94, 223-228.
    View publication on PubMed
Search for more literature for 2.5.1.6

Activating Compound

Activating Compound Comment Organism Structure
Dimethylsulfoxide activates isoform from kidney and isoform MAT-III from liver Rattus norvegicus
S-adenosylmethionine activation of rat liver MAT-III Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Dimethylsulfoxide weak inhibition of liver isoenzyme Rattus norvegicus
S-adenosylmethionine inhibition of rat kidney enzyme and rat liver MAT-II, weak inhibition of rat liver MAT-I Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
47000
-
 2 * 47000, MAT-III, SDS-PAGE Rattus norvegicus
97000
-
-
 Rattus norvegicus
120000
-
-
 Rattus norvegicus
208000
-
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-methionine + H2O Rattus norvegicus the product S-adenosylmethionine is important as a direct metabolic donor of methyl and alpha-amino-n-butyryl groups S-adenosyl-L-methionine + phosphate + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 3 isoenzymes: MAT-I, MAT-II, MAT-III
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxy-ATP + L-methionine + H2O
-
 Rattus norvegicus ?
-
 ?
3'-deoxy-ATP + L-methionine + H2O
-
 Rattus norvegicus ?
-
 ?
ATP + L-methionine + H2O
-
 Rattus norvegicus S-adenosyl-L-methionine + phosphate + diphosphate
-
 ?
ATP + L-methionine + H2O the product S-adenosylmethionine is important as a direct metabolic donor of methyl and alpha-amino-n-butyryl groups Rattus norvegicus S-adenosyl-L-methionine + phosphate + diphosphate
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 47000, MAT-III, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus