Literature summary for 2.5.1.59 extracted from

Wu, K.; Zhou, X.; Luo, Z.
Geranylgeranyltransferase I is essential for dendritic development of cerebellar Purkinje cells (2010), Mol. Brain, 3, 18.

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Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cerebellum	enzyme is abundantly expressed in the developing rat cerebellum, in particular molecular layer, the region enriched with Purkinje cell dendrites	Rattus norvegicus	-

General Information

General Information	Comment	Organism
physiological function	inhibition or down-regulation using small interference RNA inhibits dendritic development of Purkinje cells. In contrast, up-regulation of enzyme expression promotes dendritic arborization of Purkinje cells. Neuronal depolarization induced by high K+ or treatment with brain-derived neurotrophic factor BDNF promotes membrane association of Rac1 and dendritic development of Purkinje cells in cultured cerebellar slices. The effect of BDNF or high K+ is inhibited by inhibition or down-regulation of enzyme	Rattus norvegicus

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Release 2023.1 (January 2023)