Application | Comment | Organism |
---|---|---|
medicine | potential target in anticancer drug research | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-cyclohexanecarboxylic acid | IC50: 6525 nM | Homo sapiens | |
1-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-cyclohexanecarboxylic acid methyl ester | IC50: above 0.01 mM | Homo sapiens | |
2-aryl-4-aminobenzoic acid | IC50: 21 nM | Homo sapiens | |
2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-N-(3-methyl-butyl)-acetamide | IC50: above 0.01 mM | Homo sapiens | |
2-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl] acetylamino}-4-methyl-pentanoic acid methyl ester | IC50: above 0.01 mM | Homo sapiens | |
2-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-3-phenyl-propionic acid | IC50: 0.0063 mM; IC50: 170 nM | Homo sapiens | |
2-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-3-phenyl-propionic acid methyl ester | IC50: 4500 nM; IC50: above 0.01 mM | Homo sapiens | |
2-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-4-methyl-pentanoic acid | IC50: 2700 nM; IC50: 580 nM | Homo sapiens | |
2-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-4-methyl-pentanoic acid methyl ester | IC50: above 0.01 mM | Homo sapiens | |
2-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-4-methylsulfanyl-butyric acid | IC50: 3350 nM | Homo sapiens | |
2-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-4-methylsulfanyl-butyric acid methyl ester | IC50: above 0.01 mM | Homo sapiens | |
[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetic acid benzyl ester | IC50: above 0.01 mM | Homo sapiens | |
{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-acetic acid | IC50: above 0.01 mM | Homo sapiens | |
{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-acetic acid methyl ester | IC50: above 0.01 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranylgeranyl diphosphate + H-Ras-CVLL | - |
Homo sapiens | S-geranylgeranyl-protein + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PGGTase-I | - |
Homo sapiens |
protein geranylgeranyltransferase-I | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000021 | - |
IC50: 21 nM | Homo sapiens | 2-aryl-4-aminobenzoic acid | |
0.00017 | - |
IC50: 170 nM | Homo sapiens | 2-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-3-phenyl-propionic acid | |
0.00058 | - |
IC50: 580 nM | Homo sapiens | 2-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-4-methyl-pentanoic acid | |
0.0027 | - |
IC50: 2700 nM | Homo sapiens | 2-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-4-methyl-pentanoic acid | |
0.00335 | - |
IC50: 3350 nM | Homo sapiens | 2-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-4-methylsulfanyl-butyric acid | |
0.0045 | - |
IC50: 4500 nM | Homo sapiens | 2-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-3-phenyl-propionic acid methyl ester | |
0.0063 | - |
IC50: 0.0063 mM | Homo sapiens | 2-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-3-phenyl-propionic acid | |
0.006525 | - |
IC50: 6525 nM | Homo sapiens | 1-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-cyclohexanecarboxylic acid | |
0.01 | - |
IC50: above 0.01 mM | Homo sapiens | 2-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-3-phenyl-propionic acid methyl ester | |
0.01 | - |
IC50: above 0.01 mM | Homo sapiens | 2-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-4-methyl-pentanoic acid methyl ester | |
0.01 | - |
IC50: above 0.01 mM | Homo sapiens | 2-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl] acetylamino}-4-methyl-pentanoic acid methyl ester | |
0.01 | - |
IC50: above 0.01 mM | Homo sapiens | 1-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-cyclohexanecarboxylic acid methyl ester | |
0.01 | - |
IC50: above 0.01 mM | Homo sapiens | 2-{2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-4-methylsulfanyl-butyric acid methyl ester | |
0.01 | - |
IC50: above 0.01 mM | Homo sapiens | {2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-acetic acid | |
0.01 | - |
IC50: above 0.01 mM | Homo sapiens | {2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetylamino}-acetic acid methyl ester | |
0.01 | - |
IC50: above 0.01 mM | Homo sapiens | [3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetic acid benzyl ester | |
0.01 | - |
IC50: above 0.01 mM | Homo sapiens | 2-[3-(1H-imidazol-4-ylmethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-N-(3-methyl-butyl)-acetamide |