Application | Comment | Organism |
---|---|---|
medicine | S-prenylated enzymes are interesting targets for noncytotoxic anticancer agents | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | comparison of Km of 18 hexapeptides as potential substrates of the farnesyltransferase and geranylgeranyl transferaseI, recognition of overlapping sequences by farnesyltransferase and geranylgeranyltransferaseI | Rattus norvegicus | |
0.00002 | - |
Arg-Arg-Cys-Val-Leu-Leu | pH 7.6, 30°C | Rattus norvegicus | |
0.00013 | - |
Lys-Lys-Cys-Ile-Ile-Met | pH 7.6, 30°C | Rattus norvegicus | |
0.002 | - |
Lys-Pro-Cys-Val-Val-Met | pH 7.6, 30°C | Rattus norvegicus | |
0.002 | - |
Phe-Phe-Cys-Ala-Ile-Leu | pH 7.6, 30°C | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial | Rattus norvegicus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate | this enzyme, along with protein farnesyltransferase, EC 2.5.1.58 and protein geranylgeranyltransferase type II, EC 2.5.1.60, constitutes the protein prenyltransferase family of enzymes | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranylgeranyl diphosphate + Arg-Arg-Cys-Val-Leu-Leu | - |
Rattus norvegicus | diphosphate + Arg-Arg-S-geranylgeranyl-Cys-Val-Leu-Leu | - |
? | |
geranylgeranyl diphosphate + Leu-Pro-Cys-Val-Val-Met | - |
Rattus norvegicus | diphosphate + Leu-Pro-S-geranylgeranyl-Cys-Val-Val-Met | - |
? | |
geranylgeranyl diphosphate + Lys-Lys-Cys-Ile-Ile-Met | - |
Rattus norvegicus | diphosphate + Lys-Lys-S-geranylgeranyl-Cys-Ile-Ile-Met | - |
? | |
geranylgeranyl diphosphate + Lys-Pro-Cys-Val-Val-Met | - |
Rattus norvegicus | Lys-Pro-(S-geranylgeranyl)-Cys-Val-Val-Met + diphosphate | - |
? | |
geranylgeranyl diphosphate + Phe-Phe-Cys-Ala-Ile-Leu | - |
Rattus norvegicus | diphosphate + Phe-Phe-S-geranylgeranyl-Cys-Ala-Ile-Leu | - |
? | |
geranylgeranyl diphosphate + protein-cysteine | enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-aliphatic-aliphatic-X | Rattus norvegicus | S-geranylgeranyl-protein + diphosphate | - |
? | |
additional information | some of the 18 analysed hexapeptides effieciently farnsylated by enzyme | Rattus norvegicus | ? | - |
? |