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Literature summary for 2.5.1.58 extracted from

  • Wang, Y.C.; Dozier, J.K.; Beese, L.S.; Distefano, M.D.
    Rapid analysis of protein farnesyltransferase substrate specificity using peptide libraries and isoprenoid diphosphate analogues (2014), ACS Chem. Biol., 9, 1726-1735.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetic analysis Candida albicans
additional information
-
additional information kinetic analysis Rattus norvegicus
additional information
-
additional information kinetic analysis Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2E,6E)-farnesyl diphosphate + (protein)-L-cysteine Rattus norvegicus
-
S-(2E,6E)-farnesyl protein + diphosphate
-
?
(2E,6E)-farnesyl diphosphate + (protein)-L-cysteine Saccharomyces cerevisiae
-
S-(2E,6E)-farnesyl protein + diphosphate
-
?
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine Candida albicans
-
S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Candida albicans Q9Y765 alpha-subunit and beta-subunit
-
Rattus norvegicus Q04631 AND Q02293 alpha-subunit and beta-subunit
-
Saccharomyces cerevisiae P29703 AND P22007 alpha-subunit and beta-subunit
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-farnesyl diphosphate + (protein)-L-cysteine
-
Rattus norvegicus S-(2E,6E)-farnesyl protein + diphosphate
-
?
(2E,6E)-farnesyl diphosphate + (protein)-L-cysteine
-
Saccharomyces cerevisiae S-(2E,6E)-farnesyl protein + diphosphate
-
?
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine
-
Candida albicans S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate
-
?
additional information protein farnesytransferase catalyzes the farnesylation of proteins with a C-terminal tetrapeptide sequence denoted as a Ca1a2X box, determination of substrate recognition sequences, and substrate specificity, screening of the CVa2X library with alkyne-functionalized isoprenoid substrates, detailed overview Candida albicans ?
-
?
additional information protein farnesytransferase catalyzes the farnesylation of proteins with a C-terminal tetrapeptide sequence denoted as a Ca1a2X box, determination of substrate recognition sequences, and substrate specificity, screening of the CVa2X library with alkyne-functionalized isoprenoid substrates, detailed overview Rattus norvegicus ?
-
?
additional information protein farnesytransferase catalyzes the farnesylation of proteins with a C-terminal tetrapeptide sequence denoted as a Ca1a2X box, determination of substrate recognition sequences, and substrate specificity, screening of the CVa2X library with alkyne-functionalized isoprenoid substrates, detailed overview Saccharomyces cerevisiae ?
-
?

Synonyms

Synonyms Comment Organism
PFTase
-
Candida albicans
PFTase
-
Rattus norvegicus
PFTase
-
Saccharomyces cerevisiae
rPFTase
-
Candida albicans
rPFTase
-
Rattus norvegicus
rPFTase
-
Saccharomyces cerevisiae

General Information

General Information Comment Organism
additional information comparison of the substrate specificities of PFTases from three organisms, Rattus norvegicus, Saccharomyces cerevisiae, and Candida albicans, using CVa2X libraries, overview. Rattus norvegicus PFTase shares more peptide substrates with Saccharomyces cerevisiae PFTase than with Candida albicans PFTase Candida albicans
additional information comparison of the substrate specificities of PFTases from three organisms, Rattus norvegicus, Saccharomyces cerevisiae, and Candida albicans, using CVa2X libraries, overview. Rattus norvegicus PFTase shares more peptide substrates with Saccharomyces cerevisiae PFTase than with Candida albicans PFTase Rattus norvegicus
additional information comparison of the substrate specificities of PFTases from three organisms, Rattus norvegicus, Saccharomyces cerevisiae, and Candida albicans, using CVa2X libraries, overview. Rattus norvegicus PFTase shares more peptide substrates with Saccharomyces cerevisiae PFTase than with Candida albicans PFTase Saccharomyces cerevisiae