KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic analysis | Candida albicans | |
additional information | - |
additional information | kinetic analysis | Rattus norvegicus | |
additional information | - |
additional information | kinetic analysis | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + (protein)-L-cysteine | Rattus norvegicus | - |
S-(2E,6E)-farnesyl protein + diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + (protein)-L-cysteine | Saccharomyces cerevisiae | - |
S-(2E,6E)-farnesyl protein + diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine | Candida albicans | - |
S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | Q9Y765 | alpha-subunit and beta-subunit | - |
Rattus norvegicus | Q04631 AND Q02293 | alpha-subunit and beta-subunit | - |
Saccharomyces cerevisiae | P29703 AND P22007 | alpha-subunit and beta-subunit | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + (protein)-L-cysteine | - |
Rattus norvegicus | S-(2E,6E)-farnesyl protein + diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + (protein)-L-cysteine | - |
Saccharomyces cerevisiae | S-(2E,6E)-farnesyl protein + diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine | - |
Candida albicans | S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate | - |
? | |
additional information | protein farnesytransferase catalyzes the farnesylation of proteins with a C-terminal tetrapeptide sequence denoted as a Ca1a2X box, determination of substrate recognition sequences, and substrate specificity, screening of the CVa2X library with alkyne-functionalized isoprenoid substrates, detailed overview | Candida albicans | ? | - |
? | |
additional information | protein farnesytransferase catalyzes the farnesylation of proteins with a C-terminal tetrapeptide sequence denoted as a Ca1a2X box, determination of substrate recognition sequences, and substrate specificity, screening of the CVa2X library with alkyne-functionalized isoprenoid substrates, detailed overview | Rattus norvegicus | ? | - |
? | |
additional information | protein farnesytransferase catalyzes the farnesylation of proteins with a C-terminal tetrapeptide sequence denoted as a Ca1a2X box, determination of substrate recognition sequences, and substrate specificity, screening of the CVa2X library with alkyne-functionalized isoprenoid substrates, detailed overview | Saccharomyces cerevisiae | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PFTase | - |
Candida albicans |
PFTase | - |
Rattus norvegicus |
PFTase | - |
Saccharomyces cerevisiae |
rPFTase | - |
Candida albicans |
rPFTase | - |
Rattus norvegicus |
rPFTase | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
additional information | comparison of the substrate specificities of PFTases from three organisms, Rattus norvegicus, Saccharomyces cerevisiae, and Candida albicans, using CVa2X libraries, overview. Rattus norvegicus PFTase shares more peptide substrates with Saccharomyces cerevisiae PFTase than with Candida albicans PFTase | Candida albicans |
additional information | comparison of the substrate specificities of PFTases from three organisms, Rattus norvegicus, Saccharomyces cerevisiae, and Candida albicans, using CVa2X libraries, overview. Rattus norvegicus PFTase shares more peptide substrates with Saccharomyces cerevisiae PFTase than with Candida albicans PFTase | Rattus norvegicus |
additional information | comparison of the substrate specificities of PFTases from three organisms, Rattus norvegicus, Saccharomyces cerevisiae, and Candida albicans, using CVa2X libraries, overview. Rattus norvegicus PFTase shares more peptide substrates with Saccharomyces cerevisiae PFTase than with Candida albicans PFTase | Saccharomyces cerevisiae |