Literature summary for 2.5.1.58 extracted from

Chakrabarti, D.; Da Silva, T.; Barger, J.; Paquette, S.; Patel, H.; Patterson, S.; Allen, C.M.
Protein Farnesyltransferase and protein prenylation in Plasmodium falciparum (2002), J. Biol. Chem., 277, 42066-42073.

Search for more literature for 2.5.1.58

Application

Application	Comment	Organism
medicine	enzyme a target in developing drug therapy for malaria	Plasmodium falciparum

Inhibitors

Inhibitors	Comment	Organism	Structure
FTI-277	-	Plasmodium falciparum
GGTI-298	-	Plasmodium falciparum
additional information	-	Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
farnesyl diphosphate + protein-cysteine	Plasmodium falciparum	potential role for cell cycle	S-farnesyl protein + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	protozoa malaria parasite, infected erythrocytes	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	appearance during specific stages of Plasmodium falciparum differentiation	Plasmodium falciparum	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
farnesyl diphosphate + protein-cysteine	-	Plasmodium falciparum	diphosphate + S-farnesyl protein	-	?
farnesyl diphosphate + protein-cysteine	potential role for cell cycle	Plasmodium falciparum	S-farnesyl protein + diphosphate	-	?

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Release 2023.1 (January 2023)