Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
General Stability | Organism |
---|---|
protected from inactivation by presence of phosphoenolpyruvate | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5,5'-dithio-bis(2-nitrobenzoic acid) | - |
Rattus norvegicus | |
N-ethylmaleimide | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.035 | - |
N-acetyl-D-mannosamine 6-phosphate | - |
Rattus norvegicus | |
0.1 | - |
phosphoenolpyruvate | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | absolute requirement for divalent cations | Rattus norvegicus | |
Mg2+ | absolute requirement for divalent cations | Rattus norvegicus | |
Mn2+ | absolute requirement for divalent cations | Rattus norvegicus | |
additional information | Ca2+ or Cu2+ does not substitute for Mg2+ | Rattus norvegicus | |
Ni2+ | absolute requirement for divalent cations | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
37000 | - |
2 * 37000, SDS-PAGE | Rattus norvegicus |
75000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O | Escherichia coli | - |
N-acetyl-neuraminate 9-phosphate + phosphate | - |
? | |
N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O | Rattus norvegicus | - |
N-acetyl-neuraminate 9-phosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
neuB gene product amino acid sequence accession. no. | - |
Homo sapiens | Q9NR45 | amino acid sequence | - |
Rattus norvegicus | - |
rat | - |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
salivary gland | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.505 | - |
- |
Rattus norvegicus |
Storage Stability | Organism |
---|---|
4°C, crude extract retains 60% of enzyme activity when stored for 1 week | Rattus norvegicus |
4°C, purified enzyme loses activity completely after 1 day in phosphate buffer | Rattus norvegicus |
4°C, purified enzyme, 50% of enzyme activity remains after 2 days in phosphate buffer containing 5 mM MgCl2, enzyme activity is lost entirely after 3 days | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O | - |
Escherichia coli | N-acetyl-neuraminate 9-phosphate + phosphate | - |
? | |
N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O | - |
Rattus norvegicus | N-acetyl-neuraminate 9-phosphate + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 37000, SDS-PAGE | Rattus norvegicus |