Literature summary for 2.5.1.55 extracted from

Duewel, H.S.; Woodard, R.W.
A metal bridge between two enzyme families. 3-Deoxy-D-manno-octulosonate-8-phosphate synthase from Aquifex aeolicus requires a divalent metal for activity (2000), J. Biol. Chem., 275, 22824-22831.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1,10-phenanthroline	-	Aquifex aeolicus
Cd2+	10 mM	Aquifex aeolicus
Cu2+	10 mM	Aquifex aeolicus
EDTA	reactivation by divalent metal ions	Aquifex aeolicus
Mn2+	10 mM	Aquifex aeolicus
Zn2+	10 mM	Aquifex aeolicus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Cd2+	maximal activation below 0.1 mM	Aquifex aeolicus
Cu2+	maximal activation below 0.1 mM	Aquifex aeolicus
Fe2+	contains 0.2-0.3 equivalents of iron per enzyme subunit. FeSO4 stimulates	Aquifex aeolicus
Zn2+	enzyme contains approximately 0.4 equivalents of zinc per enzyme subunit. Maximal activation below 0.1 mM Zn2+	Aquifex aeolicus

Organism

Organism	UniProt	Comment	Textmining
Aquifex aeolicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant enzyme	Aquifex aeolicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphoenolpyruvate + D-arabinose 5-phosphate	-	Aquifex aeolicus	2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate	-	?
phosphoenolpyruvate + erythrose 4-phosphate	-	Aquifex aeolicus	3-deoxy-D-ribo-heptulosonate 7-phosphate	-	?

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Release 2023.1 (January 2023)