Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2S)-2,7-bis(phosphonooxy)heptanoic acid | - |
Mycobacterium tuberculosis | |
3-pyridine carboxyaldehyde | - |
Mycobacterium tuberculosis | |
4-allylpyrocatechol | - |
Mycobacterium tuberculosis | |
7-O-methylwogonin | - |
Mycobacterium tuberculosis | |
allylpyrocatechol-3,4-diacetate | - |
Mycobacterium tuberculosis | |
alpha-tocopherol | - |
Mycobacterium tuberculosis | |
beta-glucogallin | - |
Mycobacterium tuberculosis | |
boeravione | - |
Mycobacterium tuberculosis | |
campesterol | - |
Mycobacterium tuberculosis | |
chlorogenic acid | - |
Mycobacterium tuberculosis | |
degalactotigonin | - |
Mycobacterium tuberculosis | |
eclalbasaponin I | - |
Mycobacterium tuberculosis | |
eupalitin-3-O-galactoside | - |
Mycobacterium tuberculosis | |
L-phenylalanine | allosteric feedback inhibition | Mycobacterium tuberculosis | |
L-tryptophan | allosteric feedback inhibition | Mycobacterium tuberculosis | |
L-tyrosine | allosteric feedback inhibition | Mycobacterium tuberculosis | |
additional information | inhibitor screening, docking study, molecular dynamics and molecular modelling, induced fit docking scores, overview. alpha-Tocopherol, 3-pyridine carboxyaldehyde, and rutin can be drug leads to inhibit mtDAH7Ps in Mycobacterium tuberculosis | Mycobacterium tuberculosis | |
negundiside | - |
Mycobacterium tuberculosis | |
rosamarinic acid | - |
Mycobacterium tuberculosis | |
rubiadin | - |
Mycobacterium tuberculosis | |
rutin | - |
Mycobacterium tuberculosis | |
stevioside | - |
Mycobacterium tuberculosis | |
tetrahydrocurcumin | - |
Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Michaelis-Menten kinetics | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O | Mycobacterium tuberculosis | - |
3-deoxy-D-arabino-hept-2-ulosonate 7-phospate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | O53512 | gene aroG | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O | - |
Mycobacterium tuberculosis | 3-deoxy-D-arabino-hept-2-ulosonate 7-phospate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase | - |
Mycobacterium tuberculosis |
mtDAH7Ps | - |
Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.021 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | alpha-tocopherol | |
0.042 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | rutin | |
0.054 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 3-pyridine carboxyaldehyde |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme catalyzes the first step in shikimate pathway | Mycobacterium tuberculosis |