Literature summary for 2.5.1.49 extracted from

Hacham, Y.; Gophna, U.; Amir, R.
In vivo analysis of various substrates utilized by cystathionine gamma-synthase and O-acetylhomoserine sulfhydrylase in methionine biosynthesis (2003), Mol. Biol. Evol., 20, 1513-1520.

Search for more literature for 2.5.1.49

Cloned(Commentary)

Cloned (Comment)	Organism
MetY gene can complement the metB mutant of Escherichia coli	Leptospira meyeri

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
O-acetyl-L-homoserine + H2S	Saccharomyces cerevisiae	-	L-homocysteine + acetic acid	-	?
O-acetyl-L-homoserine + H2S	Leptospira meyeri	direct sulfhydrylation pathway, methionine biosynthesis	L-homocysteine + acetic acid	-	?

Organism

Organism	UniProt	Comment	Textmining
Leptospira meyeri	P94890	MetY protein sequence	-
Saccharomyces cerevisiae	P06106	Met17 protein sequence	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
O-acetyl-L-homoserine + H2S	-	Leptospira meyeri	L-homocysteine + acetic acid	-	?
O-acetyl-L-homoserine + H2S	-	Saccharomyces cerevisiae	L-homocysteine + acetic acid	-	?
O-acetyl-L-homoserine + H2S	direct sulfhydrylation pathway, methionine biosynthesis	Leptospira meyeri	L-homocysteine + acetic acid	-	?
O-acetyl-L-serine + H2S	-	Leptospira meyeri	L-cysteine + acetic acid	-	?

Synonyms

Synonyms	Comment	Organism
OAHS	-	Leptospira meyeri

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Release 2023.1 (January 2023)