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Literature summary for 2.5.1.49 extracted from

  • Morinaga, Y.; Tani, Y.; Yamada, H.
    Biosynthesis of homocysteine in a facultative methylotroph, Pseudomonas FM518 (1983), Agric. Biol. Chem., 47, 2855-2860.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
L-methionine competitive inhibition Pseudomonas sp.
S-adenosyl-L-methionine
-
Pseudomonas sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6
-
O-acetyl-L-serine
-
Pseudomonas sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
O-acetyl-L-homoserine + H2S Pseudomonas sp. direct sulfhydrylation pathway, biosynthesis of homocysteine L-homocysteine + acetic acid
-
?
O-acetyl-L-homoserine + H2S Pseudomonas sp. FM518 direct sulfhydrylation pathway, biosynthesis of homocysteine L-homocysteine + acetic acid
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas sp.
-
FM518
-
Pseudomonas sp. FM518
-
FM518
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information L-homoserine and O-succinyl-L-homoserine are no substrates Pseudomonas sp. ?
-
?
additional information L-homoserine and O-succinyl-L-homoserine are no substrates Pseudomonas sp. FM518 ?
-
?
O-acetyl-L-homoserine + H2S
-
Pseudomonas sp. L-homocysteine + acetic acid
-
?
O-acetyl-L-homoserine + H2S direct sulfhydrylation pathway, biosynthesis of homocysteine Pseudomonas sp. L-homocysteine + acetic acid
-
?
O-acetyl-L-homoserine + H2S
-
Pseudomonas sp. FM518 L-homocysteine + acetic acid
-
?
O-acetyl-L-homoserine + H2S direct sulfhydrylation pathway, biosynthesis of homocysteine Pseudomonas sp. FM518 L-homocysteine + acetic acid
-
?
O-acetyl-L-serine
-
Pseudomonas sp. L-cysteine + acetate
-
?
O-acetyl-L-serine
-
Pseudomonas sp. FM518 L-cysteine + acetate
-
?

Synonyms

Synonyms Comment Organism
OAH
-
Pseudomonas sp.

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.6
-
L-methionine O-acetylserine sulfhydrylase activity Pseudomonas sp.
15
-
L-methionine O-acetylhomoserine sulfhydrylase activity Pseudomonas sp.