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Literature summary for 2.5.1.48 extracted from

  • Flavin, M.; Slaughter, C.
    Enzymatic synthesis of homocysteine or methionine directly from O-succinyl-homoserine (1967), Biochim. Biophys. Acta, 132, 400-405.
    View publication on PubMed
Search for more literature for 2.5.1.48

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
 O-succinyl-L-homoserine pH 7.3, 30°C, reaction with H2S Salmonella enterica subsp. enterica serovar Typhimurium
0.07
-
 O-succinyl-L-homoserine pH 7.3, 30°C, gamma-replacement reaction Salmonella enterica subsp. enterica serovar Typhimurium
0.3
-
 O-succinyl-L-homoserine pH 7.3, 30°C, gamma-elimination reaction Salmonella enterica subsp. enterica serovar Typhimurium
3
-
 H2S pH 7.3, 30°C, gamma-replacement reaction Salmonella enterica subsp. enterica serovar Typhimurium
4
-
 O-succinyl-L-homoserine pH 7.3, 30°C, gamma-replacement reaction Salmonella enterica subsp. enterica serovar Typhimurium
9
-
 O-succinyl-L-homoserine pH 7.3, 30°C, reaction wirh CH3SH Salmonella enterica subsp. enterica serovar Typhimurium
100
-
 CH3SH pH 7.3, 30°C, gamma-replacement reaction Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
O-succinyl-L-homoserine + L-cysteine Salmonella enterica subsp. enterica serovar Typhimurium essential step in bacterial methionine biosynthesis L-cystathionine + succinate
-
 ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Reaction

Reaction Comment Organism Reaction ID
O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate can also use hydrogen sulfide and methanethiol as substrates producing homocysteine and methionine respectively. In the absence of thiol, the enzyme can also catalyse beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia Salmonella enterica subsp. enterica serovar Typhimurium
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
O-succinyl-L-homoserine + CH3SH
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-methionine + succinate
-
 ?
O-succinyl-L-homoserine + H2O gamma-elimination, in absence of L-cysteine Salmonella enterica subsp. enterica serovar Typhimurium succinate + 2-oxobutyrate + NH3
-
 ?
O-succinyl-L-homoserine + H2S
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-homocysteine + succinate
-
 ?
O-succinyl-L-homoserine + L-cysteine
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-cystathionine + succinate
-
 ?
O-succinyl-L-homoserine + L-cysteine essential step in bacterial methionine biosynthesis Salmonella enterica subsp. enterica serovar Typhimurium L-cystathionine + succinate
-
 ?