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Literature summary for 2.5.1.47 extracted from

  • Tahir, J.; Watanabe, M.; Jing, H.; Hunter, D.; Tohge, T.; Nunes-Nesi, A.; Brotman, Y.; Fernie, A.; Hoefgen, R.; Dijkwel, P.
    Activation of R-mediated innate immunity and disease susceptibility is affected by mutations in a cytosolic O-acetylserine (thiol) lyase in Arabidopsis (2013), Plant J., 73, 118-130.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
G162E naturally occuring mutation, the EMS-induced single nucleotide substitution in the cytosolic OASTL-A1 gene in the Ler-0 accession of Arabidopsis thaliana causes early senescence and death in plants, and is referred to as onset of leaf death3 (old3-1) Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Arabidopsis thaliana 5829
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Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana P47998 Ler-0 and Col-0, isozyme OASTL-A1, gene OASA
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Synonyms

Synonyms Comment Organism
cysteine synthase 1 UniProt Arabidopsis thaliana
O-acetylserine (thiol) lyase
-
 Arabidopsis thaliana
OASTL-A1
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 Arabidopsis thaliana
old3-1
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 Arabidopsis thaliana
protein ONSET OF LEAF DEATH 3
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 Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction lack of a functional isozyme OASTL-A1 results in enhanced disease susceptibility against infection with virulent and non-virulent Pseudomonas syringae pv. tomato DC3000 strains. Reduction of the OASTL activity of the old3-1 protein in vitro causes autonecrosis in specific Arabidopsis accessions, association of an effector triggered-like immune response and metabolic disorder with with auto-necrosis in old3 mutants. A negative epistatic interaction with the old3-1 mutation is not linked to reduced cysteine biosynthesis. Mutations in O-acetylserine (thiol) lyase regulate innate immune responses and disease susceptibility Arabidopsis thaliana
additional information auto-necrosis depends on recognition of peronospora parasitica 1 (RPP1)-like disease resistance R gene(s) from an evolutionarily divergent R gene cluster that is present in Ler-0 but not the reference accession Col-0 Arabidopsis thaliana
physiological function besides a role of OAST-A1 in cysteine biosynthesis, the enzyme is involved in regulation of plant immunity Arabidopsis thaliana